COMBINATION OF BINARY SYSTEM WITH KI67 IMMUNOHISTOCHEMICAL STAINING: A RELIABLE GRADING METHOD FOR ORAL EPITHELIAL DYSPLASIA

Combination of Binary System with Ki67 Immunohistochemical Staining: a Reliable Grading Method for Oral Epithelial Dysplasia

Statement of the Problem: Oral epithelial dysplasia (OED) is a common potentially malignant lesion of oral cavity that should be managed to prevent likely malignant transformation.Purpose: Here, we present a combination of binary grading system with complementary immunohistochemical (IHC) staining for Ki67 biomarker to provide a reproducible OED gr

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Role of Hepatic-Specific Transcription Factors and Polycomb Repressive Complex 2 during Induction of Fibroblasts to Hepatic Fate.

Direct reprogramming using defined sets of transcription factors (TFs) is a recent strategy for generating induced hepatocytes (iHeps) from fibroblasts for Grooming Kits use in regenerative medicine and drug development.Comprehensive studies detailing the regulatory role of TFs during this reprogramming process could help increase its efficiency.Th

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